SeqSIMLA reads a sequence file that contains a population of sequences (or haplotypes). The reference file is a binary compressed file (*.gz). Sequences files on chromosome 1 for the European, Chinese, and African populations are available for download on the SeqSIMLA webiste. A smaller sets of sequence files (500 kb on chromosome 1) for the three populations are also available for download. If you would like to generate your own reference sequence file, please refer to the section "Generate reference sequence file".